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Friday, September 24, 2010

Gonadal dysgenesis and Hypogonadism

Gonadal dysgenesis is the defective embryonic development of the gonads. It is characterized by a progressive loss of primordial germ cells on the developing gonads of an embryo. This leads to extremely hypoplastic (incomplete or arrested development of an organ or a part) and disfunctioning gonads mainly composed of fibrous tissue (streak gonads).

Hypogonadism is a defect of the gonads with retardation of growth, sexual development, and secondary sex characters. It is the inadequate functioning of the gonads as manifested by deficiencies in gametogenesis or the secretion of gonadal hormones.

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